Flashman, Emily: search on Z-Library

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1

Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants

Masson, Norma, Keeley, Thomas P., Giuntoli, Beatrice, White, Mark D., Puerta, Mikel Lavilla, Perata, Pierdomenico, Hopkinson, Richard J., Flashman, Emily, Licausi, Francesco, Ratcliffe, Peter J.

Journal:

Year:

2019

File:

PDF, 1.07 MB

2019

2

Structures of Arabidopsis thaliana oxygen-sensing plant cysteine oxidases 4 and 5 enable targeted manipulation of their activity

White, Mark D., Dalle Carbonare, Laura, Lavilla Puerta, Mikel, Iacopino, Sergio, Edwards, Martin, Dunne, Kate, Pires, Elisabete, Levy, Colin, McDonough, Michael A., Licausi, Francesco, Flashman, Emily

Journal:

Proceedings of the National Academy of Sciences

Year:

2020

File:

PDF, 1.30 MB

2020

3

Epigenetic regulation by histone demethylases in hypoxia

Hancock, Rebecca L, Dunne, Kate, Walport, Louise J, Flashman, Emily, Kawamura, Akane

Journal:

Year:

2015

Language:

english

File:

PDF, 2.67 MB

english, 2015

4

Studies on Deacetoxycephalosporin C Synthase Support a Consensus Mechanism for 2-Oxoglutarate Dependent Oxygenases

Tarhonskaya, Hanna, Szöllössi, Andrea, Leung, Ivanhoe K. H., Bush, Jacob T., Henry, Luc, Chowdhury, Rasheduzzaman, Iqbal, Aman, Claridge, Timothy D. W., Schofield, Christopher J., Flashman, Emily

Journal:

Year:

2014

Language:

english

File:

PDF, 2.27 MB

english, 2014

5

Cover Picture: ESI-MS Studies on Prolyl Hydroxylase Domain 2 Reveal a New Metal Binding Site (ChemMedChem 4/2008)

Jasmin Mecinović, Rasheduzzaman Chowdhury, Benoît M. R. Liénard, Emily Flashman, Matthew R. G. Buck, Neil J. Oldham, Christopher J. Schofield

Journal:

Year:

2008

Language:

english

File:

PDF, 698 KB

english, 2008

6

ESI-MS Studies on Prolyl Hydroxylase Domain 2 Reveal a New Metal Binding Site

Jasmin Mecinović, Rasheduzzaman Chowdhury, Benoît M. R. Liénard, Emily Flashman, Matthew R. G. Buck, Neil J. Oldham, Christopher J. Schofield

Journal:

Year:

2008

Language:

english

File:

PDF, 495 KB

english, 2008

7

Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen

Emily Flashman, Lee M. Hoffart, Refaat B. Hamed, J. Martin Bollinger Jr, Carsten Krebs, Christopher J. Schofield

Journal:

Year:

2010

Language:

english

File:

PDF, 473 KB

english, 2010

8

Secondary Binding Sites for Triplex-Forming Oligonucleotides Containing Bulges, Loops, and Mismatches in the Third Strand †

Fox, Keith R., Flashman, Emily, Gowers, Darren

Journal:

Year:

2000

Language:

english

File:

PDF, 748 KB

english, 2000

9

Hypoxia and hypoxia mimetics differentially modulate histone post-translational modifications

Hsu, Kuo-Feng, Wilkins, Sarah E., Hopkinson, Richard J., Sekirnik, Rok, Flashman, Emily, Kawamura, Akane, McCullagh, James S.O., Walport, Louise J., Schofield, Christopher J.

Journal:

Year:

2020

File:

PDF, 8.52 MB

2020

10

TCT-380 The Prolyl Hydroxylase Inhibitor BIQ/FG-2216 Stabilises HIF-1α and Upregulates VEGF in vitro: A Potential Strategy For Difficult CTO Lesions in Patients.

Barnett, Georgina A., Flashman, Emily, Kelly, Damien J., Schofield, Christopher J., Gershlick, Anthony

Journal:

Journal of the American College of Cardiology

Year:

2013

Language:

english

File:

PDF, 149 KB

english, 2013

11

Zinc excess induces a hypoxia-like response by inhibiting cysteine oxidases in poplar roots

Dalle Carbonare, Laura, White, Mark, Shukla, Vinay, Francini, Alessandra, Perata, Pierdomenico, Flashman, Emily, Sebastiani, Luca, Licausi, Francesco

Journal:

PLANT PHYSIOLOGY

Year:

2019

File:

PDF, 2.25 MB

2019

12

Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay

Ehrismann, Dominic, Flashman, Emily, Genn, David N., Mathioudakis, Nicolas, Hewitson, Kirsty S., Ratcliffe, Peter J., Schofield, Christopher J.

Journal:

Biochemical Journal

Year:

2007

Language:

english

File:

PDF, 350 KB

english, 2007

13

Lysine-241 has a role in coupling 2OG turnover with substrate oxidation during KDM4-catalysed histone demethylation

Hancock, Rebecca L, Abboud, Martine I, Smart, Tristan J, Flashman, Emily, Kawamura, Akane, Schofield, Christopher J, Hopkinson, Richard

Journal:

Year:

2018

Language:

english

File:

PDF, 1.48 MB

english, 2018

14

ASE publications

Barnett, Georgina A., Flashman, Emily, Kelly, Damien J., Schofield, Christopher J., Gershlick, Anthony

Journal:

Journal of the American Society of Echocardiography

Year:

2001

Language:

english

File:

PDF, 71 KB

english, 2001

15

Oxygen-sensing mechanisms across eukaryotic kingdoms and their roles in complex multicellularity

Hammarlund, Emma U., Flashman, Emily, Mohlin, Sofie, Licausi, Francesco

Journal:

Year:

2020

File:

PDF, 1.23 MB

2020

16

Support for a trimeric collar of myosin binding protein C in cardiac and fast, but not slow, skeletal muscle

Johanna Moolman-Smook, Emily Flashman, Lundi Korkie, Charles Redwood

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2007

Language:

english

File:

PDF, 152 KB

english, 2007

17

Use of ferrous iron by metallo-β-lactamases

Cahill, Samuel T., Tarhonskaya, Hanna, Rydzik, Anna M., Flashman, Emily, McDonough, Michael A., Schofield, Christopher J., Brem, Jürgen

Journal:

Journal of Inorganic Biochemistry

Year:

2016

Language:

english

File:

PDF, 1.73 MB

english, 2016

18

Dynamic states of the DNA repair enzyme AlkB regulate product release

Bleijlevens, Boris, Shivarattan, Tara, Flashman, Emily, Yang, Yi, Simpson, Pete J, Koivisto, Pertti, Sedgwick, Barbara, Schofield, Christopher J, Matthews, Steve J

Journal:

Year:

2008

Language:

english

File:

PDF, 635 KB

english, 2008

19

Investigations on the oxygen dependence of a 2-oxoglutarate histone demethylase

Sánchez‑Fernández, Elena M., Tarhonskaya, Hanna, Al‑Qahtani, Khalid, Hopkinson, Richard J., McCullagh, James S. O., Schofield, Christopher J., Flashman, Emily

Journal:

Biochemical Journal

Year:

2013

Language:

english

File:

PDF, 1.01 MB

english, 2013

20

Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents

Flashman, Emily, Davies, Sarah L., Yeoh, Kar Kheng, Schofield, Christopher J.

Journal:

Biochemical Journal

Year:

2010

Language:

english

File:

PDF, 700 KB

english, 2010

21

Structure and mechanism of a viral collagen prolyl hydroxylase

Longbotham, James E.J., Levy, Colin, Johannissen, Linus O., Tarhonskaya, Hanna, Jiang, Shuo, Loenarz, Christoph, Flashman, Emily, Hay, Sam, Schofield, Christopher J., Scrutton, Nigel S.

Journal:

Year:

2015

Language:

english

File:

PDF, 2.10 MB

english, 2015

22

Evidence for a Stereoelectronic Effect in Human Oxygen Sensing

Christoph Loenarz, Jasmin Mecinović, Rasheduzzaman Chowdhury, Luke A. McNeill, Emily Flashman, Christopher J. Schofield

Journal:

Angewandte Chemie

Year:

2009

Language:

english

File:

PDF, 535 KB

english, 2009

23

Kinetic Investigations of the Role of Factor Inhibiting Hypoxia-inducible Factor (FIH) as an Oxygen Sensor

Tarhonskaya, Hanna, Hardy, Adam P., Howe, Emily A., Loik, Nikita D., Kramer, Holger B., McCullagh, James S. O., Schofield, Christopher J., Flashman, Emily

Journal:

Journal of Biological Chemistry

Year:

2015

Language:

english

File:

PDF, 2.36 MB

english, 2015

24

YcfDRM is a thermophilic oxygen-dependent ribosomal protein uL16 oxygenase

Sekirnik, Rok, Wilkins, Sarah E., Bush, Jacob, Tarhonskaya, Hanna, Münzel, Martin, Hussein, Aayan, Flashman, Emily, Mohammed, Shabaz, McDonough, Michael A., Loenarz, Christoph, Schofield, Christopher

Journal:

Year:

2018

Language:

english

File:

PDF, 1.57 MB

english, 2018

25

Localization of the binding site of the C-terminal domain of cardiac myosin-binding protein-C on the myosin rod

Flashman, Emily, Watkins, Hugh, Redwood, Charles

Journal:

Biochemical Journal

Year:

2007

Language:

english

File:

PDF, 354 KB

english, 2007

26

OS-9: Another Piece in the HIF Complex Story

Emily Flashman, Michael A. McDonough, Christopher J. Schofield

Journal:

Year:

2005

Language:

english

File:

PDF, 75 KB

english, 2005

27

Direct Analysis of Enzyme-Catalyzed DNA Demethylation

Karkhanina, Anna A., Mecinović, Jasmin, Musheev, Michael U., Krylova, Svetlana M., Petrov, Alexander P., Hewitson, Kirsty S., Flashman, Emily, Schofield, Christopher J., Krylov, Sergey N.

Journal:

Analytical Chemistry

Year:

2009

Language:

english

File:

PDF, 1.01 MB

english, 2009

28

Hypoxia-inducible factor prolyl hydroxylase 2 has a high affinity for ferrous iron and 2-oxoglutarate

McNeill, Luke A., Flashman, Emily, Buck, Matthew R. G., Hewitson, Kirsty S., Clifton, Ian J., Jeschke, Gunnar, Claridge, Timothy D. W., Ehrismann, Dominic, Oldham, Neil J., Schofield, Christopher J.

Journal:

Molecular BioSystems

Year:

2005

Language:

english

File:

PDF, 362 KB

english, 2005

29

Investigating the contribution of the active site environment to the slow reaction of hypoxia-inducible factor prolyl hydroxylase domain 2 with oxygen

Tarhonskaya, Hanna, Chowdhury, Rasheduzzaman, Leung, Ivanhoe K. H., Loik, Nikita D., McCullagh, James S. O., Claridge, Timothy D. W., Schofield, Christopher J., Flashman, Emily

Journal:

Biochemical Journal

Year:

2014

Language:

english

File:

PDF, 700 KB

english, 2014

30

The Plant Cysteine Oxidases from Arabidopsis thaliana are kinetically tailored to act as oxygen sensors

White, Mark D., Kamps, Jos J. A. G., East, Samuel, Taylor Kearney, Leah J., Flashman, Emily

Journal:

Journal of Biological Chemistry

Year:

2018

Language:

english

File:

PDF, 852 KB

english, 2018

31

Studies on the Reaction of Nitric Oxide with the Hypoxia-Inducible Factor Prolyl Hydroxylase Domain 2 (EGLN1)

Rasheduzzaman Chowdhury, Emily Flashman, Jasmin Mecinović, Holger B. Kramer, Benedikt M. Kessler, Yves M. Frapart, Jean-Luc Boucher, Ian J. Clifton, Michael A. McDonough, Christopher J. Schofield

Journal:

Journal of Molecular Biology

Year:

2011

Language:

english

File:

PDF, 1.07 MB

english, 2011

32

Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases

Tarhonskaya, Hanna, Rydzik, Anna M., Leung, Ivanhoe K. H., Loik, Nikita D., Chan, Mun Chiang, Kawamura, Akane, McCullagh, James S. O., Claridge, Timothy D. W., Flashman, Emily, Schofield, Christopher

Journal:

Nature Communications

Year:

2014

Language:

english

File:

PDF, 702 KB

english, 2014

33

Studies on the Interaction of the Histone Demethylase KDM5B with Tricarboxylic Acid Cycle Intermediates

Tarhonskaya, Hanna, Nowak, Radoslaw P., Johansson, Catrine, Szykowska, Aleksandra, Tumber, Anthony, Hancock, Rebecca L., Lang, Pauline, Flashman, Emily, Oppermann, Udo, Schofield, Christopher J., Kawa

Journal:

Journal of Molecular Biology

Year:

2017

Language:

english

File:

PDF, 1.82 MB

english, 2017

34

Crystal Structure of the C1 domain of Cardiac Myosin Binding Protein-C: Implications for Hypertrophic Cardiomyopathy

Lata Govada, Liz Carpenter, Paula C.A. da Fonseca, John R. Helliwell, Pierre Rizkallah, Emily Flashman, Naomi E. Chayen, Charles Redwood, John M. Squire

Journal:

Journal of Molecular Biology

Year:

2008

Language:

english

File:

PDF, 1.34 MB

english, 2008

35

Catalytic strategies of the non-heme iron dependent oxygenases and their roles in plant biology

White, Mark D, Flashman, Emily

Journal:

Current Opinion in Chemical Biology

Year:

2016

Language:

english

File:

PDF, 1008 KB

english, 2016

36

Evidence for a Stereoelectronic Effect in Human Oxygen Sensing

Christoph Loenarz, Jasmin Mecinović, Rasheduzzaman Chowdhury, Luke A. McNeill, Emily Flashman, Christopher J. Schofield

Journal:

Angewandte Chemie International Edition

Year:

2009

Language:

english

File:

PDF, 535 KB

english, 2009

37

TCT-441 Enhanced Endothelial Tubule Formation in Response to Proly-Hydroxylase Inhibitor FG-2216: A Step Towards Therapeutic Angiogenesis in Chronic Total Occlusions

Georgina Barnett, Benjamin Wrigley, Damien Kelly, Emily Flashman, Christopher Schofield, Anthony Gershlick

Journal:

Journal of the American College of Cardiology

Year:

2012

Language:

english

File:

PDF, 139 KB

english, 2012

38

Using NMR Solvent Water Relaxation to Investigate Metalloenzyme−Ligand Binding Interactions

Leung, Ivanhoe K. H., Flashman, Emily, Yeoh, Kar Kheng, Schofield, Christopher J., Claridge, Timothy D. W.

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 1.34 MB

english, 2010

39

Structural Basis for Binding of Hypoxia-Inducible Factor to the Oxygen-Sensing Prolyl Hydroxylases

Rasheduzzaman Chowdhury, Michael A. McDonough, Jasmin Mecinović, Christoph Loenarz, Emily Flashman, Kirsty S. Hewitson, Carmen Domene, Christopher J. Schofield

Journal:

Year:

2009

Language:

english

File:

PDF, 1.38 MB

english, 2009

40

Ribonucleotide Reductase Requires Subunit Switching in Hypoxia to Maintain DNA Replication

Foskolou, Iosifina P., Jorgensen, Christian, Leszczynska, Katarzyna B., Olcina, Monica M., Tarhonskaya, Hanna, Haisma, Bauke, D’Angiolella, Vincenzo, Myers, William K., Domene, Carmen, Flashman, Emily

Journal:

Year:

2017

Language:

english

File:

PDF, 3.88 MB

english, 2017

41

Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants

Masson, Norma, Keeley, Thomas P., Giuntoli, Beatrice, White, Mark D., Puerta, Mikel Lavilla, Perata, Pierdomenico, Hopkinson, Richard J., Flashman, Emily, Licausi, Francesco, Ratcliffe, Peter J.

Journal:

Year:

2019

Language:

english

File:

PDF, 1.07 MB

english, 2019

42

Use of mass spectrometry to probe the nucleophilicity of cysteinyl residues of prolyl hydroxylase domain 2

Jasmin Mecinović, Rasheduzzaman Chowdhury, Emily Flashman, Christopher J. Schofield

Journal:

Analytical Biochemistry

Year:

2009

Language:

english

File:

PDF, 541 KB

english, 2009

43

The Activity of JmjC Histone Lysine Demethylase KDM4A is Highly Sensitive to Oxygen Concentrations

Hancock, Rebecca L, Masson, Norma, Dunne, Kate, Flashman, Emily, Kawamura, Akane

Journal:

ACS Chemical Biology

Year:

2017

Language:

english

File:

PDF, 7.60 MB

english, 2017

44

The most versatile of all reactive intermediates?

Flashman, Emily, Schofield, Christopher J

Journal:

Nature Chemical Biology

Year:

2007

Language:

english

File:

PDF, 761 KB

english, 2007

45

Application of a Proteolysis/Mass Spectrometry Method for Investigating the Effects of Inhibitors on Hydroxylase Structure

Stubbs, Christopher J., Loenarz, Christoph, Mecinović, Jasmin, Yeoh, Kar Kheng, Hindley, Nicola, Liénard, Benoît M., Sobott, Frank, Schofield, Christopher J., Flashman, Emily

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 1.11 MB

english, 2009

46

Studying the active-site loop movement of the São Paolo metallo-β-lactamase-1

Brem, Jürgen, Struwe, Weston B., Rydzik, Anna M., Tarhonskaya, Hanna, Pfeffer, Inga, Flashman, Emily, van Berkel, Sander S., Spencer, James, Claridge, Timothy D. W., McDonough, Michael A., Benesch, Ju

Journal:

Chemical Science

Year:

2015

Language:

english

File:

PDF, 1.15 MB

english, 2015

47

Oxygenases for oxygen sensing

Loenarz, Christoph, Chowdhury, Rasheduzzaman, Schofield, Christopher J., Flashman, Emily

Journal:

Pure & Applied Chemistry

Year:

2008

Language:

english

File:

PDF, 797 KB

english, 2008

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